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 Grouping with different players increase enemy difficulty but will also raise the quantity of loot enemies drop.  Each one has a remarkable buff but in addition a substantial penalty to think about.  At bare minimum, you want some life regeneration so you may recover health between battles.
The biggest of which is that in case you do not specifically understand what it is you're doing, you are able to very quickly end up getting a character that's too weak to do much of anything.  Especially with a character who can be turned into so many various ways. Each character is provided an extremely basic backstory, a special look, and will comment on game events in their very own voice and fashion.
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 There are widely reported desynchronization issues that could cause considerable difficulties, especially in Hardcore play.  With what was a truly excellent conference, for the very first time in a very long time, I find myself going back because I have typed this, to return and re-watch a number of the trailers.  The other thing you ought to understand is it's absolutely free to play.